A heart attack is a dangerous event and can be fatal to those affected. Researchers from Austria have now shown that an infarct not only affects the heart but also the entire organism and also affects other organs.
Good Cardiac Surgical Care in Germany
Every year around 300,000 people in Germany suffer a heart attack. In acute cases, rapid action is needed. Because a timely heart attack diagnosis saves lives. According to experts, heart surgery in Germany is generally very good. According to recent findings, a heart attack is a so-called "systemic disease", which is why future therapies should probably begin in several places in the organism. The current acute therapy is not questioned by the new knowledge.
Heart attack has consequences for the whole organism
An acute heart attack should not and should not be considered in isolation - myocardial infarction is a "systemic" disease that affects the entire organism and other organs as wellLiver and spleen react.
This is the key finding of a study conducted by PhD student Matthias Zimmermann and under the supervision of Hendrik Jan Ankersmit and Michael Mildner at the Clinical Department of Thoracic Surgery at the University Clinics of Surgery and Dermatology at MedUni Vienna.
The study results were recently published in the journal "Oncotarget".
Myocardial Infarction in Its Completeness
"With this we have stated that the tunnel vision, which is solely concerned with the heart, must be reconsidered in the event of a heart attack," said Zimmermann, according to a statement."Myocardial infarction is not isolated, the whole organism reacts with it."
Ankersmit added: "This was the first time in this descriptive science that we were able to show what myocardial infarction looks like in its entirety. This contributes enormously to the understanding of systems biology. "
So far, in standard science, attempts have mostly been made with monocausal approaches, without a holistic approach, to understand molecular and cellular processes after a heart attack( triggered by a circulatory disorder).
Very little was known about the effects on tissues and other organs surrounding the infarct center.
Future therapy should be considered systemically
The current study was conducted in a large animal model relevant to humans. The researchers were able to show that thousands of genes are involved in a heart attack:
The heart attack thus changed the expression of almost 9,000 genes in the heart, but also of 900 in the liver and around 350 in the spleen within 24 hours after infarction.
At the same time, the transcription factor Klf4( a protein that is important for the activation of many other genes) could be attributed a significant role - this "large animal insight" could also be confirmed by histological studies on human autopsy material.
The central message of this work: "Myocardial ischemia, ie myocardial infarction, does not end in the injured myocardium. Our results show that the spectrum of organs involved is much larger and there are many indications that a variety of organ systems are involved in coordinating an organism's response to the infarction. "
The new findings do not support common acute heart attack therapyin
question - but open the discussion of whether a future therapy should not be considered systemically and should begin in several places in the organism.(ad)