Too much cholesterol is unhealthy for the human body. Too high cholesterol increases the risk of heart disease, stroke, and some types of cancer. Researchers now found out that too much cholesterol appears to be an additional burden on the cartilage between the bones. This can ultimately lead to the development of osteoarthritis.
The researchers at Queensland University of Technology found that a too high cholesterol increases the risk of osteoarthritis. The physicians published the results of their study in the journal "Federation of American Societies for Experimental Biology"( FASEB).
What is cholesterol actually and where is it produced?
Cholesterol is a waxy substance and is mainly produced in the liver, although most other body cells can produce cholesterol. Cholesterol is important for human health. It is used by the body to produce hormones, vitamin D, bile acids and cell membranes, say the medicines. There are two main types of cholesterol. The good cholesterol HDL and the bad or unhealthy cholesterol LDL.The HDL cholesterol removes the LDL cholesterol from the circulation and transports it back to the liver for processing. The unhealthy cholesterol LDL is associated with an increased risk of cardiovascular disease, the experts explain.
Physicians produce knee injuries in test animals as in humans with arthrosis
For the study, two groups of rodents were examined. In one of the groups the genes were altered in such a way that the animals showed too high cholesterol values in their blood. The doctors performed a surgical procedure with the test animals with too high cholesterol values to produce similar knee injuries as with people with arthrosis. Animals with high cholesterol levels often showed a more severe disease development compared to animals with normal cholesterol, scientists say.
High cholesterol levels can kill cells and lead to arthritis
A high cholesterol level triggers so-called mitochondrial oxidative stress for human cartilage cells, As a result, these cells die and arthrosis develops, explains Dr. Dr. Indira Prasadam from the Queensland University of Technology.
Nutrition and Medications Can Prevent Osteoarthritis
The team of medical professionals has already begun to educate the public to a healthier diet along with nutritional counselors. This is to keep the cholesterol level at a manageable level. In this way, damage to the joints can also be avoided. The researchers also found that the drug atorvastatin is able to reduce the development of osteoarthritis. When the mice and rats were treated with the drug atorvastatin and antioxidants acting specifically on mitochondria, the development of arthrosis was reduced.(as)