So-called genetic portraits of cancer patients can improve the survival probability without the health condition worsening in this additional time. Through the genetic images the identification of personalized therapeutic targets can be improved. Researchers found that one-third of all treated patients experienced at least a 30% increase in survival-free survival.
The scientists at the Gustave Roussy Cancer Campus in France found that the use of genetic portraits in cancer patients can significantly increase the probability of survival. Many of the patients( about a third) lived longer without their condition worsening. The physicians publish the results of their study at the so-called Map( Molecular Analysis for Personalized Therapy) conference in London.
Does the analysis of the DNA of tumor samples lead to an improvement in the treatment?
The aim of the new study was to determine whether an analysis of the DNA of tumor samples can actually lead to an improvement in the treatment of cancer patients, the authors explain. For this purpose, the samples of more than 1,000 subjects with a wide range of disease types were analyzed. These diseases included, for example, lung, breast, head and neck, prostate, bladder, bowel and stomach cancer, the medical doctors add.
Genetic sequencing should lead to better therapeutic decisions
The DNA of the tumor was sequenced by the collected samples. Thus, mutations can be found, which may be better treated by special drugs, the researchers explain. The primary aim of the study was to enable the gene sequencing to make better therapeutic decisions. This improved form of treatment could improve survival in at least 25 percent of advanced metastatic cancer patients, explains Professor Jean-Charles Soria, from the Gustave Roussy Cancer Campus in Paris.
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Treatment Increases Survival Probability in 33 Percent of Patients
The final results showed that whole 33 percent of patientshave an improved survival probability, the authors say. This is the first precise medical study to show the improvements in treatment options by DNA analysis in patients with advanced cancer.
Experimental drugs can slow tumor growth
Scientists have also found that, in some cases( one in five patients), experimental drugs can slow the growth of tumors in patients with advanced cancer. In 411 patients( approximately 49 percent of all samples provided), an attack point was found for treatment in the genes of those affected. Approximately half of these patients were then treated with a so-called ADHOC therapy.
Affected survived between 5 and 32 months
The improvement in the survival rate was between five and 32 months. The time that tumors needed to re-grow was compared with the results of previous treatments."It is fantastic to see what efforts are being made in this area of research," the researchers emphasize. Now it is very important to make the best of the data collected up to the present time, the medical experts explain further.(as)